HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Griffin, D G Search for Related Content PubMed PubMed Citation Articles by Griffin, D G Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB AMMONIUM OXALATE CALCIUM COMPOUNDS CALCIUM, ELEMENTAL

A review of the heritability of idiopathic nephrolithiasis

Correspondence to:
Dr D G Griffin
Department of Chemical Pathology, Morriston Hospital, Swansea SA6 6NL, UK; damian.griffin{at}swansea-tr.wales.nhs.uk
ABSTRACT
Familial aggregations of nephrolithiasis were already noted in the early 19th century and over the intervening years there has been gradual progression in classifying the familial forms of nephrolithiasis. To date, there are at least 10 different monogenic conditions where those affected have a predisposition to nephrolithiasis. However, all of these rare conditions probably account for less than 2% of renal stone formers. This review, rather than considering these clearly defined disorders, concentrates on research into the broad band of stone formers who have a propensity to nephrolithiasis without an obvious discrete genetic basis.

Keywords: hypercalciuria; hyperoxaluria; inheritance; nephrolithiasis; segregation analysis