© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
CASE REPORT
Atypical haemolytic uraemic syndrome as a complication of induction chemotherapy for acute lymphoblastic leukaemia
Birmingham Children’s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK
Correspondence to:
Correspondence to:
Dr D Chandra
Department of Paediatric Haematology, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK; deepak.chandra{at}bch.nhs.uk
This report describes a case of fatal haemolytic uraemic syndrome (HUS) developing in a child with acute lymphoblastic leukaemia (ALL) during induction chemotherapy. The aetiology in this case is uncertain but it may have resulted from treatment with L-asparaginase or vincristine. The possibility of HUS during induction chemotherapy for ALL should be considered early on in the treatment regimen, if clinical signs and symptoms suggest this diagnosis, so that appropriate treatment can be instituted.
Keywords: haemolytic uraemic syndrome; acute lymphoblastic leukaemia; TTP
Abbreviations: ALL, acute lymphoblastic leukaemia; CT, computed tomography; HUS, haemolytic uraemic syndrome; TTP, thrombotic thrombocytopenic purpura
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