© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
CASE REPORT
Treatment difficulties of a listerial rhombencephalitis in an adult patient allergic to penicillins
1 Infectious Diseases Department, Regional Hospital Orléans, France and "Matei Bals" Infectious Diseases Institute, Bucharest, Romania
2 Intensive Care Unit, Regional Hospital Orléans, France
3 Microbiology Department, Regional Hospital Orléans
4 Infectious Diseases Department, Regional Hospital Orléans
Correspondence to:
Correspondence to:
G A Popescu
Str. Brebu, nr.4, bl. T 11, ap. 12, sector 2, Bucharest, Romania; gabrielp9{at}yahoo.com
Rhombencephalitis is not a rare presentation of listerial central nervous system infections in healthy adults. This report describes a case with several management difficulties linked to antibiotic related adverse events, pointing to alternative solutions to aminopenicillins. In addition, the role of dexamethasone in the management of inflammation and neurological symptoms is discussed.
Keywords: Listeria monocytogenes; rhombencephalitis; antimicrobial treatment; adverse events; dexamethasone
Abbreviations: CNS, central nervous system; CT, computed tomography; CSF, cerebrospinal fluid; RE, rhombencephalitis; TMP/STX, trimethoprim-sulfamethoxazole; WBC, white blood cell count
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