© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
CASE REPORT
Sudden death of a patient with primary hypereosinophilia, colon tumours, and pulmonary emboli
1 Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
2 Department of Human and Diagnostic Pathology, Graduate School of Medicine, University of Tokyo
Correspondence to:
Correspondence to:
Dr K Uemura
Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; kuemura{at}m.u-tokyo.ac.jp
A 33 year old man was admitted to hospital six days after the onset of abdominal pain. There was hypereosinophilia, but the cause could not be identified (primary hypereosinophilia). The hypereosinophilia, high C reactive protein concentration, and gastrointestinal symptoms were alleviated by corticosteroid treatment. Unexpectedly, after this apparent recovery, he was found dead on the 27th day after admission. Necropsy disclosed two solid tumours primarily composed of eosinophils in the ascending and transverse colon. The cause of the sudden death was pulmonary artery emboli, derived from a thrombus in the left iliac vein.
Keywords: hypereosinophilia syndrome; solid tumour; sudden death; pulmonary artery emboli; major basic protein
Abbreviations: HE, hypereosinophilia
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