HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miliaras, D Articles by Sioutopoulou, D Search for Related Content PubMed PubMed Citation Articles by Miliaras, D Articles by Sioutopoulou, D

KIT expression in fetal, normal adult, and neoplastic renal tissues

¹ Laboratory of Histology and Embryology, Medical School, Aristotle University of Thessaloniki, GR54006 Thessaloniki, Greece
² Department of Pathology, General Clinic of Thessaloniki, GR54645 Thessaloniki, Greece
³ Department of Pathology, Hippokrateion General Hospital, GR54639 Thessaloniki, Greece

Correspondence to:
Dr D Miliaras
Laboratory of Histology and Embryology, Medical School, Aristotle University of Thessaloniki, GR54006 Thessaloniki, Greece; miliaras{at}auth.gr Background: KIT is a transmembrane tyrosine kinase receptor, expressed in high amounts in various normal cells. In addition, c-kit mutation or activation is a major pathogenetic event in certain tumours (such as gastrointestinal stromal tumours). There are only limited data in the literature on the expression of KIT in normal and neoplastic renal tissues.

Aims: To investigate KIT expression in normal and neoplastic renal tissues.

Methods: KIT expression was evaluated by means of immunohistochemistry in paraffin wax embedded sections from 67 tissue samples.

Results: Eight of eight fetal kidneys, and 10 of 10 normal adult kidneys revealed cytoplasmic staining of renal tubules. The three cases of renal dysplasia studied expressed KIT in their normal and aberrant tubules. Two of 13 conventional renal cell carcinomas (RCCs), two of seven papillary type RCCs, four of seven chromophobe type RCCs, none of six nephroblastomas, seven of seven oncocytomas, two of two mesoblastic nephromas, and two of four angiomyolipomas were positive.

Conclusion: KIT is expressed in normal fetal and adult renal tubules, and in a subset of renal tumours. The expression of KIT in these renal tumours may prove to have diagnostic relevance and/or therapeutic implications.

Keywords: KIT; renal cell carcinoma; oncocytoma; angiomyolipoma; mesoblastic nephroma

Abbreviations: CMN, congenital mesoblastic nephroma; GIST, gastrointestinal stromal tumour; RCC, renal cell carcinoma; SCF, stem cell factor

This article has been cited by other articles:

				C. Jones, M. Rodriguez-Pinilla, M. Lambros, D. Bax, B. Messahel, G. M Vujanic, J. S Reis-Filho, and K. Pritchard-Jones c-KIT overexpression, without gene amplification and mutation, in paediatric renal tumours J. Clin. Pathol., November 1, 2007; 60(11): 1226 - 1231. [Abstract] [Full Text] [PDF]