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Journal of Clinical Pathology 2004;57:1245-1249
© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists


REVIEW

Aneuploidy and malignancy: an unsolved equation

P Dey

Correspondence to:
Dr P Dey
Pathology Department, Kuwait Cancer Control Centre, PO Box 42262, 70653 Shuwaikh, Kuwait; deypranab{at}hotmail.com
ABSTRACT
Aneuploidy is frequently noted in malignant tumours. There is much controversy about its cause and effect in relation to malignant tumours. Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. Telomere dysfunction may also be a possible source of failure of cytokinesis resulting in aneuploidy. Evidence such as tumour specific aneuploidy, presence of aneuploidy in various preneoplastic conditions, increased frequency of genetic instability in aneuploid cell lines compared with diploid cells, and mutation of mitotic checkpoint genes suggests that aneuploidy possibly plays an active role in carcinogenesis. In this brief review, the various aspects of aneuploidy with special emphasis on its mechanism of development and impact on progression of cancer are discussed.


Abbreviations: APC, anaphase promoting complex; CGH, comparative genomic hybridisation; FCM, flow cytometry; FISH, fluorescence in situ hybridisation; ICM, image cytometry

Keywords: aneuploidy; cancer; mitosis; mitotic checkpoint; genomic instability




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