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HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease

Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK

Correspondence to:
Dr E J Soilleux
Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK; ejs17{at}cam.ac.uk
ABSTRACT
The process by which hepatitis C virus (HCV) enters cells and the reason for its hepatotropism remain obscure. Recently, the human immunodeficiency virus (HIV) binding lectins, DC-SIGN and DC-SIGNR, were shown to bind HCV. This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism.

Keywords: DC-SIGN; DC-SIGNR; hepatitis C; liver sinusoid

Abbreviations: DC, dendritic cell; DC-SIGN, dendritic cell specific intercellular adhesion molecule grabbing non-integrin; DC-SIGNR, dendritic cell specific intercellular adhesion molecule grabbing non-integrin related molecule; HCV, hepatitis C virus; HIV, human immunodeficiency virus