© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
LETTER TO JCP
Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV
Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK
Correspondence to:
Correspondence to:
Dr E J Soilleux
Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY UK; ejs17{at}cam.ac.uk
This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/macrophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual transmission of HIV in the foreskin, by enabling infection of permissive cells in cis and/or in trans.
Keywords: human immunodeficiency virus; DC-SIGN; coreceptor; foreskin; transmission
Abbreviations: DC-SIGN, dendritic cell specific intercellular cell adhesion molecule grabbing non-integrin; HIV, human immunodeficiency virus
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This article has been cited by other articles:
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(2004). Facilitation of HIV transmission in the foreskin. Sex. Transm. Infect.
80: 81-81
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