© 2003 BMJ Publishing Group Ltd. & Association of Clinical Pathologists
LETTER TO JCP
Pneumocystis carinii, cytomegalovirus, and severe transient immunodeficiency
1 Bristol Royal Hospital for Children, Bristol BS2 8BJ, UK
2 Southmead Hospital, Bristol BS10 5ND, UK
Correspondence to:
Correspondence to:
Dr D J Unsworth, Southmead Hospital, Bristol BS10 5ND, UK;
joeunsworth{at}hotmail.com
Pneumocystis carinii infection is rare in infants, and raises strong concerns of immune deficiency. This report describes the unusual case of a male infant with concurrent chest infections caused by P carinii and cytomegalovirus. Investigation was complicated by the strong suspicion of non-accidental injury, including subdural haematomas. The case illustrates how to investigate for possible immunodeficiency. Low immune function tests at presentation slowly improved and have remained normal on longterm follow up. Possible explanations for the transient severe clinical immunodeficiency in this case are discussed.
Keywords: Pneumocystis carinii; cytomegalovirus; immune deficiency
Abbreviations: CMV, cytomegalovirus; CT, computerised tomography; HIGM, hyper-IgM syndrome; HIV, human immunodeficiency virus; SCID, severe combined immunodeficiency
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Compound via MeSHSubstance via MeSHMedline Plus Health Information Cytomegalovirus InfectionsPneumocystis InfectionsHazardous Substances DB GANCICLOVIRTRIMETHOPRIM/SULFAMETHOXAZOLE
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