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Clear cell carcinoma of the breast with solid papillary pattern: a case report with immunohistochemical profile

Department of Pathology, Kocaeli University, Medical School, 41900, Derince, Kocaeli, Turkey

Correspondence to:
Dr S K Özkara, Mustafa Pasa Mahallesi, Bagdat Caddesi, 0712. Sokak, No: 19/6, 41400, Gebze, Kocaeli, Turkey;
Erkacar{at}sisecam.com.tr
ABSTRACT
Glycogen rich clear cell carcinoma of the breast is a rare neoplasm with different morphological characteristics to ordinary breast carcinomas. However, it has some common features with clear cell carcinomas of other organs. This report describes a case of clear cell carcinoma of the breast with a solid papillary pattern centrally localised in the left breast of a 45 year old woman. Antibodies directed against cytokeratin 7 (CK7), CK10, CK14, CK17, CK18, CK19, CK20, CK5/6/18, CK8/18, high molecular weight cytokeratin AE3, high molecular weight cytokeratin 34ßE12, the oestrogen receptor, the progesterone receptor, chromogranin, S-100 protein, smooth muscle actin, vimentin, and carcinoembryogenic antigen were applied to analyse the immunophenotypical profile of this rare neoplasm.

Keywords: glycogen rich clear cell carcinoma; breast; immunohistochemistry

Abbreviations: CCC, clear cell carcinoma; CEA, carcinoembryogenic antigen; CK, cytokeratin; CR, chromogranin; ER, oestrogen receptor; HMWCK, high molecular weight cytokeratin; PAS, periodic acid Schiff; PR, progesterone receptor; RCC, renal cell carcinoma; SMA, smooth muscle actin