HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burchill, S A Search for Related Content PubMed PubMed Citation Articles by Burchill, S A

Ewing’s sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities

Correspondence to:
Dr S A Burchill, Candlelighter’s Children’s Cancer Research Laboratory, Cancer Research UK Clinical Centre, St James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK;
s.a.burchill{at}leeds.ac.uk
ABSTRACT
The identification of the non-random chromosome rearrangements between the EWS gene on chromosome 22q12 and members of the ETS gene family in Ewing’s sarcoma, peripheral primitive neuroectodermal tumour, Askin tumour, and neuroepithelioma has been a key advance in understanding their common histogenesis and defining the Ewing’s sarcoma family of tumours (ESFT). In addition to improvements in diagnosis and potentially the stratification of patients for risk, biological investigations of these gene fusions may define targets for much needed therapeutic strategies to eliminate minimal residual disease or metastatic disease. Insight into their relation with other oncogenic events in ESFT will advance risk group analysis and ultimately may improve clinical management and survival for patients with this disease.

Keywords: Ewing’s sarcoma; diagnosis; prognosis; treatment; translocations

Abbreviations: ESFT, Ewing’s sarcoma family of tumours; Euro EWING 99, European Ewing tumour working initiative of national groups 99; FISH, fluorescent in situ hybridisation; pPNET, peripheral primitive neuroectodermal tumour; RT-PCR, reverse transcriptase polymerase chain reaction

This article has been cited by other articles:

				O. Slater and J. Shipley Clinical relevance of molecular genetics to paediatric sarcomas J. Clin. Pathol., November 1, 2007; 60(11): 1187 - 1194. [Abstract] [Full Text] [PDF]

				J.-Y. Pierga and J. S. Reis-Filho Ewing's Sarcoma of the Rectum: Can We Afford Not to Use Molecular Pathology? J. Clin. Oncol., October 20, 2005; 23(30): 7761 - 7762. [Full Text] [PDF]

				O. M. Tirado, S. Mateo-Lozano, and V. Notario Roscovitine Is an Effective Inducer of Apoptosis of Ewing's Sarcoma Family Tumor Cells In vitro and In vivo Cancer Res., October 15, 2005; 65(20): 9320 - 9327. [Abstract] [Full Text] [PDF]

				H. Guan, S.-F. Jia, Z. Zhou, J. Stewart, and E. S. Kleinerman Herceptin Down-Regulates HER-2/neu and Vascular Endothelial Growth Factor Expression and Enhances Taxol-Induced Cytotoxicity of Human Ewing's Sarcoma Cells In vitro and In vivo Clin. Cancer Res., March 1, 2005; 11(5): 2008 - 2017. [Abstract] [Full Text] [PDF]