REVIEW

Cell kinetics and cell cycle regulation in lymphomas

L Leoncini, S Lazzi, C Bellan and P Tosi

Institute of Pathological Anatomy and Histology, University of Siena, 53100 Siena, Italy

Correspondence to:
Correspondence to:
Professor L Leoncini, Institute of Pathological Anatomy and Histology, University of Siena, Strada delle Scotte 6, 53100 Siena, Italy;
leoncinil{at}unisi.it

The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas.

Keywords: cell kinetics; cell cycle; malignant lymphomas

Abbreviations: BLL, Burkitt-like lymphoma; AI, apoptotic index; BL, Burkitt's lymphoma; eBL endemic CDK, cyclin dependent kinase; BLBCL, diffuse large B cell lymphoma; Burkitt's lymphona; eBL, endemic Burkitt's lymphoma; EBV, Epstein-Barr virus; HRS, Hodgkin-Reed Sternberg cells; IAP, inhibitor of apoptosis protein; Ig, immunoglobulin; LMP-1, latent membrane protein 1; MCL, mantle cell lymphoma; MI, mitotic index; MPF, M phase promoting factor; NF-B, nuclear factor B; NHL, non-Hodgkin's lymphoma; NPM, nucleophosmin; pRb, retinoblastoma protein; REAL, revised European-American classification of lymphoid neoplasm; SLVL, splenic lymphoma with villous lymphocytes; SMZL, sBL, sporadic Burkitts lymphoma; splenic marginal zone lymphoma

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