Register for email alerts and news feeds:
This journal | BMJ Group
rss
Journal of Clinical Pathology 2002;55:226-229
Copyright © 2002 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.
Journal of Clinical Pathology 2002;55:226-229
© 2002 Journal of Clinical Pathology

CASE REPORT

Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma. A case report of a patient with hereditary multiple exostoses

J V M G Bovée1, R J B Sakkers2, M J A Geirnaerdt3, A H M Taminiau2 and P C W Hogendoorn1

1 Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, 2300 RC Leiden, The Netherlands
2 Department of Orthopaedic Surgery, Leiden University Medical Center
3 Department of Radiology and Nuclear Medicine, Leiden University Medical Center

Correspondence to:
Correspondence to:
Dr P C W Hogendoorn, Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, 2300 RC Leiden, The Netherlands;
P.C.W.Hogendoorn{at}lumc.nl

ABSTRACT

A 40 year old man with hereditary multiple exostoses (HME), affecting predominantly his left proximal tibia, distal femur, and proximal femur, underwent resection of an osteochondroma near the trochanter major of his left proximal femur because of malignant transformation of the cartilaginous cap towards secondary peripheral chondrosarcoma. The patient had a history of a papillary thyroid carcinoma four years previously. At examination of the resected specimen, a third malignant tumour, an intermediate grade osteosarcoma (grade II/IV), was found in the osseous stalk of the osteochondroma. Although no mutations were found in the EXT1 and EXT2 genes, the genes involved in HME, or in exons 5–8 of the p53 gene, the development of three malignancies before the age of 40 suggests that this patient is genetically prone to malignant transformation.

Keywords: osteochondroma; hereditary multiple exostoses; chondrosarcoma; osteosarcoma

Abbreviations: HME, hereditary multiple exostoses; MR, magnetic resonance; PCR, polymerase chain reaction; SSCP, single strand conformational polymorphism


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This Article

Services
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Pathology jobs

Pathology jobs