HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, X Y Articles by Tytgat, G N J Search for Related Content PubMed PubMed Citation Articles by Chen, X Y Articles by Tytgat, G N J Pubmed/NCBI databases Medline Plus Health Information Stomach Disorders

Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa

¹ Department of Pathology, Renji Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Disease, Shanghai 200001, China
² Department of Gastroenterology, Shanghai Second Medical University
³ Department of Gastroenterology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 A2, Amsterdam, The Netherlands

Correspondence to:
Dr X Y Chen, Department of Pathology, Renji Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Disease, Shanghai 200001, China;
xiaoyu64{at}public7.sta.net.cn Aim: To investigate the relation between Helicobacter pylori associated gastroduodenal diseases and lymphoid tissue hyperplasia in the antral mucosa and to pursue its evolution after eradication of H pylori.

Methods: Gastric antral biopsy specimens were obtained from 438 patients with H pylori positive gastroduodenal diseases (185 chronic gastritis, 69 gastric ulcer, and 184 duodenal ulcer) and 50 H pylori negative healthy controls. Lymphoid follicles and aggregates were counted and other pathological features were scored according to the updated Sydney system for classification of chronic gastritis. After a course of anti-H pylori treatment, biopsy specimens were obtained at four to six weeks, 12 months, and 24 months in the chronic gastritis patient group.

Results: The total prevalence of lymphoid follicles and aggregates in the biopsies was 79.9% (350 of 438; 95% confidence intervals (CI), 0.76 to 0.84). The prevalence and density of lymphoid follicles and aggregates were significantly different in the various gastroduodenal diseases. The highest prevalence (89.9%; 95% CI, 0.83 to 0.97) and density (0.82) of lymphoid follicles and aggregates occurred in patients with gastric ulcers. The lowest prevalence of lymphoid follicles and aggregates was found in patients with chronic gastritis (74.6%; 95% CI, 0.68 to 0.81), and the lowest density of lymphoid follicles and aggregates (0.56) was seen in patients with duodenal ulcers. The prevalence and density of lymphoid follicles and aggregates correlated strongly with the activity and severity of gastric antral mucosal inflammation. The eradication of H pylori resulted in a decrease in the prevalence and density of lymphoid follicles and aggregates.

Conclusion: The prevalence and density of lymphoid follicles and aggregates in gastric antral mucosal biopsies correlated closely with H pylori infection.

Keywords: Helicobacter pylori associated gastroduodenal diseases; lymphoid follicles; lymphoid aggregates; eradication

Abbreviations: CI, confidence interval; IL, interleukin; IM, intestinal metaplasia

This article has been cited by other articles:

				D I Campbell and J E Thomas Helicobacter pylori infection in paediatric practice Arch. Dis. Child. Ed. Pract., August 1, 2005; 90(2): ep25 - ep30. [Full Text] [PDF]