REVIEW

HPV infections and lung cancer

K J Syrjänen

Correspondence to:
Correspondence to:
Professor K Syrjänen, Unità di Citoistopatologia, Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Viale Regina Elena, 299, I-00161 Roma, Italy;
kasyrjan{at}libero.it

Because of the major clinical impact of bronchial cancer worldwide, the possibility that human papillomavirus (HPV) contributes to its pathogenesis as a co-carcinogen is an intriguing one. Bronchial squamous cell carcinoma develops through well defined precursor lesions, often at the sites of squamous metaplasia. Benign squamous cell papillomas are rare but HPV DNA has been found in almost half of those studied, implicating a causal association. In invasive bronchial cancer, morphological changes seen in HPV lesions elsewhere are often seen. HPV DNA has been detected in 21.7% of the 2468 bronchial carcinomas analysed to date and the same high risk types implicated in other squamous cell cancers have been identified. Clearly, more effort should be focused on assessing the role of HPV in bronchial carcinogenesis, by analysing the synergistic effects of carcinogenic agents (cigarette smoke, radiation, asbestos, etc) and HPV in different experimental settings.

Keywords: human papillomavirus; bronchus cancer papilloma aetiology

Abbreviations: DCC, deleted in colon carcinoma; HPV, human papillomavirus; IHC, immunohistochemistry; ISH, in situ hybridisation; PCR, polymerase chain reaction; RRP, recurrent respiratory papillomatosis; SSC, squamous cell carcinoma; SSCP, single stranded conformational polymorphism; SCJ, squamo-columnar junction; SCP, squamous cell papilloma

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