© 2002 Journal of Clinical Pathology
CASE REPORT
Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant
1 Department of Immunology, Southmead Hospital, Bristol, BS10 5NB, UK
2 Department of Immunology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Correspondence to:
Correspondence to:
Dr M M Gompels, Department of Immunology, Southmead Hospital, Bristol BS10 5NB, UK;
boblock75{at}hotmail.com
A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to complete clearance of the fungal infection, although the patient subsequently died.
Keywords: Scedosporium apiospermum; chronic granulomatous disease; infection; bone marrow transplantation
Abbreviations: CGD, chronic granulomatous disease; CRP, C reactive protein; IFN-
, interferon ; HLA, human leucocyte antigen; PHLS, Public Health Laboratory Service
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