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Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma

Department of Histopathology, Royal Bolton Hospital, Minerva Road, Farnworth, Bolton BL4 0JR, UK
Department of Pathology, Christie Hospital NHS Trust, Manchester M20 4BX, UK

Dr Hanson isabelle.hanson{at}boltonh-tr.nwest.nhs.uk Sclerosing epithelioid fibrosarcoma is a recently described sarcoma in which ultrastructural evidence of fibroblastic differentiation forms part of the diagnostic criteria. This report describes a further case of this tumour, which showed evidence of both fibroblastic and perineurial differentiation by immunohistochemistry and electron microscopy, and which had areas of high grade morphology. The tumour metastasised and the patient died of disease 12 months after presentation. The relevance of these findings to diagnosis and differentiation in these tumours is discussed.

Key Words: sclerosing epithelioid fibrosarcoma • nerve sheath differentiation • high grade morphology

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