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Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment

T P Baglin

Haematology Department, Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK

Correspondence to:
Dr Baglin tpb20{at}cam.ac.uk

Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of this disease in recent years.

Key Words: heparin induced thrombocytopenia • thrombosis • immune complexes • platelet aggregating factor

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