Short report

Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease)

U Mahadeva¹, T Allport², B Bain³ and W K Chan¹

¹ Department of Histopathology, St Mary's Hospital, Praed Street, London W2 1NY, UK
² Department of Paediatrics, St Mary's Hospital
³ Department of Haematology, St Mary's Hospital

Correspondence to:
Dr Mahadeva, Department of Histopathology, Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK

A young boy presented with a rash, fever, and cervical lymphadenopathy, originally thought to be caused by tuberculosis. A lymph node biopsy showed the features of Kikuchi's disease, with necrosis and histiocytic infiltration without neutrophils. No evidence of tuberculosis was found on staining, culture, or the polymerase chain reaction. Bone marrow biopsy revealed prominent haemophagocytosis, and a diagnosis of haemophagocytic syndrome was reached. The aetiology of haemophagocytic syndrome, and its association with Kikuchi's lymphadenitis, is discussed.

Key Words: Kikuchi's disease • histiocytic necrotising lymphadenitis • histiocytic haemophagocytosis • haemophagocytic syndrome

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