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Examination of large intestine resection specimens

S H Burroughs¹ and G T Williams¹

¹ Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

Correspondence to:
Professor Williams email: WilliamsGT{at}cf.ac.uk

Macroscopic examination of large intestinal resection specimens by the surgical pathologist provides important diagnostic and prognostic information. This review summarises current recommended protocols and evidence based guidelines for gross description, dissection, and histological block selection in both neoplastic and non-neoplastic colorectal disease. Specific lesions discussed include colorectal cancer, polypectomies and polyposis syndromes, and inflammatory bowel disease. Microscopic examination is briefly described, with emphasis on certain pitfalls that might be encountered in routine practice. A section covering special techniques for the investigation of occult bleeding is included. J Clin Pathol(J Clin Pathol 2000;53:344–349)

Key Words: large intestine • colorectal cancer • inflammatory bowel disease

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