Simple method of estimating severity of pulmonary fibrosis on a numerical scale.

T Ashcroft, J M Simpson, V Timbrell

Freeman Hospital, Newcastle upon Tyne.

A continuous numerical scale for determining the degree of fibrosis in lung specimens was devised for correlation with other pulmonary variables such as lung function tests or mineral burden. Grading was scored on a scale from 0 to 8, using the average of microscope field scores. The system allows fibrosis to be measured in small samples of tissue (1 cm) which can provide a detailed description of the changes in a lung, currently not possible with most existing methods.

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• Azuma, M., Nishioka, Y., Aono, Y., Inayama, M., Makino, H., Kishi, J., Shono, M., Kinoshita, K., Uehara, H., Ogushi, F., Izumi, K., Sone, S. (2007). Role of {alpha}1-Acid Glycoprotein in Therapeutic Antifibrotic Effects of Imatinib with Macrolides in Mice. Am. J. Respir. Crit. Care Med. 176: 1243-1250 [Abstract] [Full Text]  
• Faress, J. A., Nethery, D. E., Kern, E. F. O., Eisenberg, R., Jacono, F. J., Allen, C. L., Kern, J. A. (2007). Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2. J. Appl. Physiol. 103: 2077-2083 [Abstract] [Full Text]  
• He, M., Kubo, H., Ishizawa, K., Hegab, A. E., Yamamoto, Y., Yamamoto, H., Yamaya, M. (2007). The role of the receptor for advanced glycation end-products in lung fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L1427-L1436 [Abstract] [Full Text]  
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• Suzuki, M., Sakurai, Y., Masunaga, S., Kinashi, Y., Nagata, K., Maruhashi, A., Ono, K. (2007). A Preliminary Experimental Study of Boron Neutron Capture Therapy for Malignant Tumors Spreading in Thoracic Cavity. Jpn J Clin Oncol 0: hym022v1-5 [Abstract] [Full Text]  
• Watanabe, M., Matsuyama, W., Shirahama, Y., Mitsuyama, H., Oonakahara, K.-i., Noma, S., Higashimoto, I., Osame, M., Arimura, K. (2007). Dual Effect of AMD3100, a CXCR4 Antagonist, on Bleomycin-Induced Lung Inflammation. J. Immunol. 178: 5888-5898 [Abstract] [Full Text]  
• Cuzzocrea, S., Genovese, T., Failla, M., Vecchio, G., Fruciano, M., Mazzon, E., Di Paola, R., Muia, C., La Rosa, C., Crimi, N., Rizzarelli, E., Vancheri, C. (2007). Protective effect of orally administered carnosine on bleomycin-induced lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L1095-L1104 [Abstract] [Full Text]  
• Higashiyama, H., Yoshimoto, D., Okamoto, Y., Kikkawa, H., Asano, S., Kinoshita, M. (2007). Receptor-activated Smad localisation in Bleomycin-induced pulmonary fibrosis. J. Clin. Pathol. 60: 283-289 [Abstract] [Full Text]  
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• Ishii, Y., Fujimoto, S., Fukuda, T. (2006). Gefitinib Prevents Bleomycin-induced Lung Fibrosis in Mice. Am. J. Respir. Crit. Care Med. 174: 550-556 [Abstract] [Full Text]  
• Kimura, T., Ishii, Y., Yoh, K., Morishima, Y., Iizuka, T., Kiwamoto, T., Matsuno, Y., Homma, S., Nomura, A., Sakamoto, T., Takahashi, S., Sekizawa, K. (2006). Overexpression of the Transcription Factor GATA-3 Enhances the Development of Pulmonary Fibrosis. Am. J. Pathol. 169: 96-104 [Abstract] [Full Text]  
• Inayama, M., Nishioka, Y., Azuma, M., Muto, S., Aono, Y., Makino, H., Tani, K., Uehara, H., Izumi, K., Itai, A., Sone, S. (2006). A Novel I{kappa}B Kinase-beta Inhibitor Ameliorates Bleomycin-induced Pulmonary Fibrosis in Mice. Am. J. Respir. Crit. Care Med. 173: 1016-1022 [Abstract] [Full Text]  
• Volmer, J. B., Thompson, L. F., Blackburn, M. R. (2006). Ecto-5'-Nucleotidase (CD73)-Mediated Adenosine Production Is Tissue Protective in a Model of Bleomycin-Induced Lung Injury. J. Immunol. 176: 4449-4458 [Abstract] [Full Text]  
• Matsuyama, W., Watanabe, M., Shirahama, Y., Hirano, R., Mitsuyama, H., Higashimoto, I., Osame, M., Arimura, K. (2006). Suppression of Discoidin Domain Receptor 1 by RNA Interference Attenuates Lung Inflammation. J. Immunol. 176: 1928-1936 [Abstract] [Full Text]  
• Hartwig, M. G., Appel, J. Z., Li, B., Hsieh, C.-C., Yoon, Y. H., Lin, S. S., Irish, W., Parker, W., Davis, R. D. (2006). Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation. J. Thorac. Cardiovasc. Surg. 131: 209-217 [Abstract] [Full Text]  
• Murakami, S., Nagaya, N., Itoh, T., Kataoka, M., Iwase, T., Horio, T., Miyahara, Y., Sakai, Y., Kangawa, K., Kimura, H. (2006). Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L59-L65 [Abstract] [Full Text]  
• Chunn, J. L., Molina, J. G., Mi, T., Xia, Y., Kellems, R. E., Blackburn, M. R. (2005). Adenosine-Dependent Pulmonary Fibrosis in Adenosine Deaminase-Deficient Mice. J. Immunol. 175: 1937-1946 [Abstract] [Full Text]  
• Nakashima, N, Kuwano, K, Maeyama, T, Hagimoto, N, Yoshimi, M, Hamada, N, Yamada, M, Nakanishi, Y (2005). The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. J. Clin. Pathol. 58: 583-589 [Abstract] [Full Text]  
• Aono, Y., Nishioka, Y., Inayama, M., Ugai, M., Kishi, J., Uehara, H., Izumi, K., Sone, S. (2005). Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice. Am. J. Respir. Crit. Care Med. 171: 1279-1285 [Abstract] [Full Text]  
• Genovese, T., Mazzon, E., Paola, R. D., Muia, C., Threadgill, M. D., Caputi, A. P., Thiemermann, C., Cuzzocrea, S. (2005). Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and the Development of Bleomycin-Induced Lung Injury. J. Pharmacol. Exp. Ther. 313: 529-538 [Abstract] [Full Text]  
• Howell, D. C.J., Johns, R. H., Lasky, J. A., Shan, B., Scotton, C. J., Laurent, G. J., Chambers, R. C. (2005). Absence of Proteinase-Activated Receptor-1 Signaling Affords Protection from Bleomycin-Induced Lung Inflammation and Fibrosis. Am. J. Pathol. 166: 1353-1365 [Abstract] [Full Text]  
• Genovese, T., Cuzzocrea, S., Di Paola, R., Mazzon, E., Mastruzzo, C., Catalano, P., Sortino, M., Crimi, N., Caputi, A. P., Thiemermann, C., Vancheri, C. (2005). Effect of rosiglitazone and 15-deoxy-{Delta}12,14-prostaglandin J2 on bleomycin-induced lung injury. Eur Respir J 25: 225-234 [Abstract] [Full Text]  
• Azuma, A., Li, Y. J., Abe, S., Usuki, J., Matsuda, K., Henmi, S., Miyauchi, Y., Ueda, K., Izawa, A., Sone, S., Hashimoto, S., Kudoh, S. (2005). Interferon-{beta} Inhibits Bleomycin-Induced Lung Fibrosis by Decreasing Transforming Growth Factor-{beta} and Thrombospondin. Am. J. Respir. Cell Mol. Bio. 32: 93-98 [Abstract] [Full Text]  
• Murakami, S., Nagaya, N., Itoh, T., Fujii, T., Iwase, T., Hamada, K., Kimura, H., Kangawa, K. (2004). C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L1172-L1177 [Abstract] [Full Text]  
• Hodges, R. J., Jenkins, R. G., Wheeler-Jones, C. P.D., Copeman, D. M., Bottoms, S. E., Bellingan, G. J., Nanthakumar, C. B., Laurent, G. J., Hart, S. L., Foster, M. L., McAnulty, R. J. (2004). Severity of Lung Injury in Cyclooxygenase-2-Deficient Mice Is Dependent on Reduced Prostaglandin E2 Production. Am. J. Pathol. 165: 1663-1676 [Abstract] [Full Text]  
• Desai, S. R., Veeraraghavan, S., Hansell, D. M., Nikolakopolou, A., Goh, N. S. L., Nicholson, A. G., Colby, T. V., Denton, C. P., Black, C. M., du Bois, R. M., Wells, A. U. (2004). CT Features of Lung Disease in Patients with Systemic Sclerosis: Comparison with Idiopathic Pulmonary Fibrosis and Nonspecific Interstitial Pneumonia. Radiology 232: 560-567 [Abstract] [Full Text]  
• Inoue, T., Fujishima, S., Ikeda, E., Yoshie, O., Tsukamoto, N., Aiso, S., Aikawa, N., Kubo, A., Matsushima, K., Yamaguchi, K. (2004). CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Eur Respir J 24: 49-56 [Abstract] [Full Text]  
• Kakugawa, T., Mukae, H., Hayashi, T., Ishii, H., Abe, K., Fujii, T., Oku, H., Miyazaki, M., Kadota, J., Kohno, S. (2004). Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis. Eur Respir J 24: 57-65 [Abstract] [Full Text]  
• Ebina, M., Shimizukawa, M., Shibata, N., Kimura, Y., Suzuki, T., Endo, M., Sasano, H., Kondo, T., Nukiwa, T. (2004). Heterogeneous Increase in CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 169: 1203-1208 [Abstract] [Full Text]  
• Berman, J. S., Serlin, D., Li, X., Whitley, G., Hayes, J., Rishikof, D. C., Ricupero, D. A., Liaw, L., Goetschkes, M., O'Regan, A. W. (2004). Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L1311-L1318 [Abstract] [Full Text]  
• Kimura, T., Ishii, Y., Morishima, Y., Shibuya, A., Shibuya, K., Taniguchi, M., Mochizuki, M., Hegab, A. E., Sakamoto, T., Nomura, A., Sekizawa, K. (2004). Treatment with {alpha}-Galactosylceramide Attenuates the Development of Bleomycin-Induced Pulmonary Fibrosis. J. Immunol. 172: 5782-5789 [Abstract] [Full Text]  
• Adachi, K., Suzuki, M., Sugimoto, T., Yorozu, K., Takai, H., Uetsuka, K., Nakayama, H., Doi, K. (2003). Effects of Granulocyte Colony-Stimulating Factor (G-CSF) on Bleomycin-Induced Lung Injury of Varying Severity. Toxicol Pathol 31: 665-673 [Abstract]  
• Ishii, H., Mukae, H., Kakugawa, T., Iwashita, T., Kaida, H., Fujii, T., Hayashi, T., Kadota, J.-i., Kohno, S. (2003). Increased expression of collagen-binding heat shock protein 47 in murine bleomycin-induced pneumopathy. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L957-L963 [Abstract] [Full Text]  
• Suzuki, H., Aoshiba, K., Yokohori, N., Nagai, A. (2003). Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Augments a Murine Model of Pulmonary Fibrosis. Cancer Res. 63: 5054-5059 [Abstract] [Full Text]  
• Kuwano, K., Nakashima, N., Inoshima, I., Hagimoto, N., Fujita, M., Yoshimi, M., Maeyama, T., Hamada, N., Watanabe, K., Hara, N. (2003). Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias. Eur Respir J 21: 232-240 [Abstract] [Full Text]  
• Li, Y., Azuma, A., Takahashi, S., Usuki, J., Matsuda, K., Aoyama, A., Kudoh, S. (2002). Fourteen-Membered Ring Macrolides Inhibit Vascular Cell Adhesion Molecule 1 Messenger RNA Induction and Leukocyte Migration: Role in Preventing Lung Injury and Fibrosis in Bleomycin-Challenged Mice. Chest 122: 2137-2145 [Abstract] [Full Text]  
• (2002). Spoken sessions. Thorax 57: iii3-47 [Full Text]  
• Lok, S.S., Haider, Y., Howell, D., Stewart, J.P., Hasleton, P.S., Egan, J.J. (2002). Murine gammaherpes virus as a cofactor in the development of pulmonary fibrosis in bleomycin resistant mice. Eur Respir J 20: 1228-1232 [Abstract] [Full Text]  
• Matsuoka, H., Arai, T., Mori, M., Goya, S., Kida, H., Morishita, H., Fujiwara, H., Tachibana, I., Osaki, T., Hayashi, S. (2002). A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L103-L112 [Abstract] [Full Text]  
• Tanino, Y., Makita, H., Miyamoto, K., Betsuyaku, T., Ohtsuka, Y., Nishihira, J., Nishimura, M. (2002). Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L156-L162 [Abstract] [Full Text]  
• Simler, N.R., Howell, D.C.J., Marshall, R.P., Goldsack, N.R., Hasleton, P.S., Laurent, G.J., Chambers, R.C., Egan, J.J. (2002). The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats. Eur Respir J 19: 1124-1127 [Abstract] [Full Text]  
• WANG, H.-D., YAMAYA, M., OKINAGA, S., JIA, Y.-X., KAMANAKA, M., TAKAHASHI, H., GUO, L.-Y., OHRUI, T., SASAKI, H. (2002). Bilirubin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats. Am. J. Respir. Crit. Care Med. 165: 406-411 [Abstract] [Full Text]  
• Oury, T. D., Thakker, K., Menache, M., Chang, L.-Y., Crapo, J. D., Day, B. J. (2001). Attenuation of Bleomycin-Induced Pulmonary Fibrosis by a Catalytic Antioxidant Metalloporphyrin. Am. J. Respir. Cell Mol. Bio. 25: 164-169 [Abstract] [Full Text]  
• YASUI, H., GABAZZA, E. C., TAMAKI, S., KOBAYASHI, T., HATAJI, O., YUDA, H., SHIMIZU, S., SUZUKI, K., ADACHI, Y., TAGUCHI, O. (2001). Intratracheal Administration of Activated Protein C Inhibits Bleomycin-induced Lung Fibrosis in the Mouse. Am. J. Respir. Crit. Care Med. 163: 1660-1668 [Abstract] [Full Text]  
• Keerthisingam, C. B., Jenkins, R. G., Harrison, N. K., Hernandez-Rodriguez, N. A., Booth, H., Laurent, G. J., Hart, S. L., Foster, M. L., McAnulty, R. J. (2001). Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-{beta} in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice. Am. J. Pathol. 158: 1411-1422 [Abstract] [Full Text]  
• Takahashi, F., Takahashi, K., Okazaki, T., Maeda, K., Ienaga, H., Maeda, M., Kon, S., Uede, T., Fukuchi, Y. (2001). Role of Osteopontin in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Bio. 24: 264-271 [Abstract] [Full Text]  
• Krishna, G., Liu, K., Shigemitsu, H., Gao, M., Raffin, T. A., Rosen, G. D. (2001). PG490-88, a Derivative of Triptolide, Blocks Bleomycin-Induced Lung Fibrosis. Am. J. Pathol. 158: 997-1004 [Abstract] [Full Text]  
• SHIMIZU, Y., DOBASHI, K., IIZUKA, K., HORIE, T., SUZUKI, K., TUKAGOSHI, H., NAKAZAWA, T., NAKAZATO, Y., MORI, M. (2001). Contribution of Small GTPase Rho and Its Target Protein ROCK in a Murine Model of Lung Fibrosis. Am. J. Respir. Crit. Care Med. 163: 210-217 [Abstract] [Full Text]  
• DOHI, M., HASEGAWA, T., YAMAMOTO, K., MARSHALL, B. C. (2000). Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 162: 2302-2307 [Abstract] [Full Text]  
• ZHANG, X. Y., SHIMURA, S., MASUDA, T., SAITOH, H., SHIRATO, K. (2000). Antisense Oligonucleotides to NF-kappa B Improve Survival in Bleomycin-induced Pneumopathy of the Mouse. Am. J. Respir. Crit. Care Med. 162: 1561-1568 [Abstract] [Full Text]  
• HAGIWARA, S.-I., ISHII, Y., KITAMURA, S. (2000). Aerosolized Administration of N-Acetylcysteine Attenuates Lung Fibrosis Induced by Bleomycin in Mice. Am. J. Respir. Crit. Care Med. 162: 225-231 [Abstract] [Full Text]  
• SATO, N., SUZUKI, Y., NISHIO, K., SUZUKI, K., NAOKI, K., TAKESHITA, K., KUDO, H., MIYAO, N., TSUMURA, H., SERIZAWA, H., SUEMATSU, M., YAMAGUCHI, K. (2000). Roles of ICAM-1 for Abnormal Leukocyte Recruitment in the Microcirculation of Bleomycin-induced Fibrotic Lung Injury. Am. J. Respir. Crit. Care Med. 161: 1681-1688 [Abstract] [Full Text]  
• TAMAGAWA, K., TAOOKA, Y., MAEDA, A., HIYAMA, K., ISHIOKA, S., YAMAKIDO, M. (2000). Inhibitory Effects of a Lecithinized Superoxide Dismutase on Bleomycin-Induced Pulmonary Fibrosis in Mice. Am. J. Respir. Crit. Care Med. 161: 1279-1284 [Abstract] [Full Text]  
• van Scott, M. R., Justice, J. P., Bradfield, J. F., Enright, E., Sigounas, A., Sur, S. (2000). IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L667-L674 [Abstract] [Full Text]  
• Wild, J. S., Sigounas, A., Sur, N., Siddiqui, M. S., Alam, R., Kurimoto, M., Sur, S. (2000). IFN-{gamma}-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma. J. Immunol. 164: 2701-2710 [Abstract] [Full Text]  
• Keane, M. P., Belperio, J. A., Arenberg, D. A., Burdick, M. D., Xu, Z. J., Xue, Y. Y., Strieter, R. M. (1999). IFN-{gamma}-Inducible Protein-10 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Angiogenesis. J. Immunol. 163: 5686-5692 [Abstract] [Full Text]  
• Sur, S., Wild, J. S., Choudhury, B. K., Sur, N., Alam, R., Klinman, D. M. (1999). Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides. J. Immunol. 162: 6284-6293 [Abstract] [Full Text]  
• El-Gamel, A., Awad, M., Sim, E., Hasleton, P., Yonan, N., Egan, J., Deiraniya, A., Hutchinson, I. V. (1999). Transforming growth factor-{beta}1 and lung allograft fibrosis. Eur. J. Cardiothorac. Surg. 13: 424-430 [Abstract] [Full Text]  
• Yaekashiwa, M, Nakayama, S, Ohnuma, K, Sakai, T, Abe, T, Satoh, K, Matsumoto, K, Nakamura, T, Takahashi, T, Nukiwa, T (1997). Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am. J. Respir. Crit. Care Med. 156: 1937-1944 [Abstract] [Full Text]  
• TAOOKA, Y., MAEDA, A., HIYAMA, K., ISHIOKA, S., YAMAKIDO, M. (1997). Effects of Neutrophil Elastase Inhibitor on Bleomycin-Induced Pulmonary Fibrosis in Mice. Am. J. Respir. Crit. Care Med. 156: 260-265 [Abstract] [Full Text]  
• (1997). Corrigenda for vol. 155, p. 1367. Am. J. Respir. Crit. Care Med. 156: 676-677 [Full Text]