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Journal of Clinical Pathology 1979;32:35-39; doi:10.1136/jcp.32.1.35
Copyright © 1979 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.

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A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.

E Heyderman, K Steele, M G Ormerod

Using antisera raised against defatted human cream we have demonstrated a new antigen on the epithelial membrane. An indirect immunoperoxidase technique on routinely processed histological sections was used, and we describe results which show that this antigen has a widespread but highly selective distribution, being apparently localised to membranes that have a secretory function. The antigen is carried by a variety of adenocarcinomas, suggesting that its localisation may have a role in the diagnosis and differential diagnosis of malignant disease.




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Copyright © 1979 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.